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KMID : 0359320180580030137
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Korean Journal of Veterinary Research
2018 Volume.58 No. 3 p.137 ~ p.141
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Evaluation of the efficacy of an attenuated live vaccine based on virulent porcine reproductive and respiratory syndrome virus 2 in young pigs
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Lee Seung-Chul
Noh Yun-Hee
Lee Sun-Hee
Choi Hwan-Won
Yoon In-Joong
Kang Shien-Young
Lee Chang-Hee
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Abstract
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The efficacy of the CA-2-MP120 vaccine, a cell culture-attenuated strain of virulent porcine reproductive and respiratory syndrome virus (PRRSV), was assessed in pigs. Despite the persistence of viremia in all vaccinated animals during the immunization period, the virus was not detected in vaccinated pigs following challenge. Furthermore, no pigs in the vaccinated group shed PRRSV nasally, orally or rectally throughout the experiment. Moreover, histopathological lung and lymph node lesions in the immunized group were much milder than those in the unimmunized and challenged group. These results indicated that CA-2-MP120 can provide effective protection against virulent wildtype PRRSV-2.
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KEYWORD
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attenuated vaccines, porcine reproductive and respiratory syndrome virus, treatment outcome, vaccination
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